Bomb explosions against iconic and public buildings have become hazardous due to widespread terrorist activities in various parts of the world. Loss of life and properties worth millions are the consequences of such terror attacks. Most buildings which are likely to be the target of a terrorist bomb have been constructed without considering their vulnerability, or their potential to mitigate the impact. The design and construction of public buildings to provide life safety in the face of explosions is receiving renewed attention from structural engineers. Such concern arose initially in response to air attacks during World War II, it continued through the Cold War and more recently this concern has grown with the increase of terrorism worldwide. The analysis of the structural failure of a reinforced concrete building caused by a blast load is presented in this paper. All the process from the detonation of the explosive charge to the complete demolition, including the propagation of the blast wave and its interaction with the structure is reproduced. The analysis was carried out with a hydrocode. The problem analyzed corresponds to an actual building that has suffered a terrorist attack. The paper includes comparisons with photographs of the real damage produced by the explosive charge that validates all the simulation procedure.