At present buildings with floating column is a typical feature in the modern multistory construction in urban India. There are many projects in which floating columns are adopted, especially above the ground floor, where transfer girders are employed, so that more open space is available in the ground floor. As the load path in the floating columns is not continuous, they are more vulnerable to the seismic activity. Sometimes, to meet the requirements these type of aspects cannot be avoided though these are not found to be of safe. Hence, an attempt is taken to study the behavior of a G+15 multi storey building in which some storey’s are considered for commercial purpose and remaining storey’s are for residential purpose. This paper studies the comparison & seismic analysis of the multistory buildings with floating column and without floating column. Finally, analysis & results in the high rise building such as storey drifts, storey displacement, and Base shear were shown in this study. Design and Analysis was carried out by using Extended Three Dimensional Analysis of Building Systems (ETABS) Software.