This manual is intended to provide a technical resource for bridge engineers responsible for seismic analysis and design. It serves as a reference manual for use with the 5-day National Highway Institute (NHI) 130093 course “LRFD Seismic Analysis and Design of Bridges”, and the 3-day 130093A course “Displacement-Based LRFD Seismic Analysis and Design of Bridges”. The manual covers fundamental topics such as engineering seismology; seismic and geotechnical hazards; structural dynamics (SDOF and MDOF); and methods for modeling and analyzing bridges subject to earthquake ground motions. It also presents the principles of capacity design; applications of capacity design to piers, foundations, superstructures and connections; and discusses the requirements and recommendations of the seismic provision in each of the AASHTO LRFD Bridge Design Specifications and AASHTO Guide Specifications for LRFD Seismic Bridge Design, and their common features. Lastly, the manual addresses seismic isolation design in accordance with AASHTO Guide Specifications for Seismic Isolation Design, and retrofitting strategies in accordance with the 2006 FHWA Seismic Retrofitting Manual for Highway Structures.