This paper describes an investigation has been carried out to examine the most common structural systems that are used for reinforced concrete tall buildings under the action of gravity and wind loads. These systems include “Rigid Frame”, “Shear Wall/Central Core”, “Wall- Frame Interaction”, and “Outrigger”. The basic modeling technique and assumptions are made by “ETABS” Program, in 3-D modeling. Design considerations are made according to Indian Standards. This comparative analysis has been aimed to select the optimal structural system for a certain building height. The structural efficiency is measured by the time period, storey displacement, drift, lateral displacement, base shear values and core moments. The recommendations for each structural are based upon limiting the wind drift of the structure, and increasing the lateral stiffness. The achievement of structural system for tall buildings is not an easy task. Whereas building height increases the importance of lateral loads action rises in an accelerating rate. There are two types of lateral loads, wind and seismic loads. Wind load presents the most critical lateral loading for modern tall buildings, which have lightweight skeletons that cause uncomfortable horizontal movements for occupants. Also, wind is not constant either with height or with time and is not uniform over the sides of a building. So, windy weather creates a variety of problems in tall buildings, causing concern for buildings owner and engineers alike. Where, excessive vibration due to this load is a major obstacle in design and construction of a modern tall building. It should be limited to prevent both structural and non-structural damage.