In this research paper, the effect of wind velocity and structural response of building frame on sloping ground has been studied. Considering various frame geometries and slope of grounds. Combination of static and wind loads are considered. For combination, 60 cases in different wind zones and three different heights of building frames are analysed. STAAD-Pro v8i software has been used for analysis purpose. Results are collected in terms of axial force, Shear force, moment, support reaction, Storey-wise drift and Displacement which are critically analysed to quantify the effects of various slope of ground.